XVIVO’s Modern Preservation Expertise Used within the World’s First Ever Profitable Coronary heart Xenotransplantation (Pig to Human)

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On January 7, 2022, the world’s first ever profitable pig to human coronary heart transplantation happened, a groundbreaking milestone for the sector of transplantation. A staff on the College of Maryland Faculty of Medication, USA, carried out the process. The recipient was a 57-year-old terminally in poor health man who obtained a coronary heart from a gene-modified pig. After retrieval, the pig coronary heart was preserved with XVIVO’s coronary heart perfusion system and proprietary resolution till transplanted.

Organ scarcity is the best problem going through the transplant area at the moment. Consequently, solely a small variety of sufferers with finish stage coronary heart illness is given the chance of a transplant and lots of die whereas ready for a brand new organ. A possible resolution to this essential scarcity is xenotransplantation, which implies transplantation between species.

Groundbreaking analysis, using XVIVOs coronary heart preservation expertise, has lately achieved long-term survival after xenotransplants of hearts from gene-modified pigs to primates. Primarily based on this in depth analysis the primary ever transplantation of a coronary heart from a genetically modified pig to a human has now taken place.

The affected person didn’t qualify to obtain a standard human organ transplant, and because of his terminal coronary heart illness, xenotransplant was the one accessible possibility for his survival. He’s nonetheless doing effectively three days after the historic surgical procedure.

XVIVO has developed a novel methodology for storing and transporting donated hearts in an optimized means, via non-ischemic coronary heart preservation (NIHP) in collaboration with Professor Stig Steen and Igelösa Life Science in Lund, Sweden. The XVIVO coronary heart perfusion system preserves the donor coronary heart at 8 C˚ whereas repeatedly pumping an oxygenated, propriety resolution via the organ. The primary transplants with human donors have efficiently been carried out and several other medical trials at main transplant facilities in Europe and Australia are ongoing. In 2019, XVIVO’s new coronary heart expertise was granted ‘Breakthrough Machine Designation’ from the U.S. Meals and Drug Administration (FDA) and a multicenter medical trial is deliberate within the US for 2022.

The brand new coronary heart preservation expertise is meant for medical human to human transplants, however it has additionally been demonstrated to be pivotal for long run survival in pre-clinical analysis utilizing pig hearts for xenotransplantation by mitigating the danger of early organ dysfunction.

Muhammad M. Mohiuddin, MD, Professor of Surgical procedure on the College of Maryland Faculty of Medication, has been concerned within the area of xenotransplantation since 1992. “I am along with Dr Bart Griffith heading a big and highly-skilled staff, and collectively we made this occur. A few years of analysis and preclinical efforts by us and others led us so far. The transplanted affected person had a life-threatening situation with no passable various remedy. I’m completely happy to say that his progress is on the observe and he’s in excellent spirit. With out XVIVO’s new coronary heart expertise this transplant would by no means have occurred, and I’m grateful for all assist we’ve obtained”, says Professor Mohiuddin.

“In a future the place xenotransplants can assist resolve the donor organ scarcity we’re actually residing our imaginative and prescient that no person ought to die ready for a brand new organ. We’ve all the time been within the forefront of organ expertise and innovation. Subsequently, it’s nothing greater than a real honor to be a part of this primary ever profitable cardiac pig to human xenotransplant that might convey further hope for sufferers on the ready listing. To me, that is the final word proof that collaboration between scientists, clinicians and the business is making the world a greater place”, says Dag Andersson, XVIVO CEO.

Please observe the hyperlink to the press launch from the College of Maryland Faculty of Medication:

January 10, 2022
XVIVO Perfusion AB (publ)

For additional data, please contact:

Dag Andersson, CEO, +46 31-788 21 50, dag.andersson@xvivogroup.com

About Us

Based in 1998, XVIVO is the one medical expertise firm devoted to extending the lifetime of all main organs – so transplant groups around the globe can save extra lives. Our options enable main clinicians and researchers to push the boundaries of transplantation drugs. XVIVO is headquartered in Gothenburg, Sweden, and has places of work and analysis websites on two continents. The corporate is listed on Nasdaq and has the ticker image XVIVO. Extra data might be discovered on the web site www.xvivogroup.com.


XVIVO’s progressive preservation expertise used on the planet’s first ever profitable coronary heart xenotransplantation (pig to human)


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